Endocrine Abstracts

Background: Thyroid hormones modulate the lipoprotein and glucose metabolisms. In hyperthyroidism, insulin resistance is a frequent finding.Aim: To assess interrelationships between thyroid function, autoimmunity, lipid profile, glucose metabolism and other cardiovascular risk factors in patients with Graves’ disease.Methods: We recorded free T3 (FT3), free T4 (FT4), TSH, TSH receptor antibodies (TRAB), parameters of the lipid...

Introduction: Optimization of iodine intake aims to prevent the irreversible damage that iodine deficiency (ID) can cause in the central nervous system during its development, as well as thyroid disorders that can be induced by both ID and excessive micronutrient intake. The Spanish legal regulation stipulates that iodized salt (IS) must contain 60 mg of iodine per kg of salt (60 ppm), allowing a tolerance of ±15%. The aim of this study is to address the iodine content of...

The use of gallium-68 (68Ga) is rapidly expanding with new applications arising almost every week. Therefore, the global availability of this nuclide is a critical issue. 68Ga is currently sourced from commercial 68Ge/68Ga generators but their production is limited by the availability of the parent nuclide 68Ge. Alternatively, the use of a 68Zn salt solution in a liquid target has been proposed [1] [2]. With thi...

Introduction: In patients with autoimmune thyroiditis, thyroid function appears to be related to increased cardiovascular risk. It was our objective to evaluate the relationship between TSH, insulin resistance, lipid profile, C-reactive protein (CRP) and homocysteine in patients with autoimmune thyroiditis (AIT).Methods: We analyzed the lipid profile, the CRP, anti-thyroid antibodies, homocysteine, folic acid, vitamin B12 levels and the insulin resistanc...

Introduction: Ghrelin is a gastrointestinal peptide involved in the regulation of body weight and energy balance. However, its behavior after bariatric surgery and its relationship with other biochemical variables is still under discussion. We aim to undertake a simultaneous evaluation of the changes in ghrelin levels after three types of bariatric surgery and its relationship with different variables.Design: The study included 21 non-obese and 103 morbi...

Somatostatin (SST) and cortistatin (CORT) are two highly related neuropeptides involved in the regulation of several endocrine secretions. In particular, SST and CORT are two primary negative regulators of GH secretion. Consequently, SST or CORT knockout (KO) mice exhibit elevated GH levels; however, this does not lead to increased IGF-I levels or somatic growth, which has been suggested that could be due to a compensatory mechanism between both peptides. In order to test this...

Introduction: Subclinical hypothyroidism appears to be related with an increased risk of cardiovascular disease. It was our objective to evaluate the relationship between autoimmune thyroiditis, subclinical hypothyroidism, and cardiovascular risk factors.Methods: We evaluated thyroid function tests, autoimmunity, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, ApoA1, ApoB, Lp(a), homocysteine, high sensibility CPR, folic acid, vitamin...

Diabetes is associated with a greatly increased risk of cardiovascular disease and the advanced glycation end products (AGEs) and their receptors play an important role in these complications.Objective: To study the association between AGEs and sRAGE levels with cardiovascular risk factors in obese and non-obese newly diagnosed type 2 diabetic patients.Material and methods: We conducted a cross-sectional study in subjects with type...

Objective: To evaluate the interrelationships between thyroid function, insulin resistance, lipid profile, homocysteine, C-reactive protein (CRP), folic acid, and vitamin B12 levels, in Graves’ disease (GD).Methods: We recorded thyroid function tests, BMI, insulin resistance markers, lipid profile, homocysteine, CRP, folic acid, and vitamin B12 levels, in 104 subjects with GD in the first cycle of treatment with methimazole, 94% of whom were female....

Introduction: Thyroid dysfunction is a common health problem. Its prevalence may vary in different populations, and in Spain, it has not been sufficiently studied. The aim of this study was to evaluate the prevalence of thyroid dysfunction (clinical and subclinical) in our country.Materials and methods: The diabetes study is a national, cross-sectional, population-based survey. Target population: the entire Spanish population >18 years. Sample: >...